In this interview series we focus on a general overview of the anticoagulants and the new agents. Dr. Jeffrey Weitz (Hamilton, Canada) provides an overview on the older and newer anticoagulants. He shares through examples which patient characteristics should be considered in choosing the right anticoagulant for each patient. Dr. Alex Spyropoulos (New York, NY) explains the risks and the benefits of the Newer Agents based on clinical studies. Dr. Jerrold Levy (Durham, NC) highlights the new oral agents Dabigatran, Rivaroxaban, Apixiban.